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This allows collection of enormous quantities of cell culture data, including total and viable cell density, viability, cell diameter, pH, PCO2, PO2, glucose, lactate, glutamine, glutamate, ammonium, Na+, K+, Ca++, and osmolality, which can be sampled and measured with a complete cycle time of just 6–7 minutes. Nova’s BioProfile® FLEX2 automated cell culture analyzer.Combining the ambr® 15 and the BioProfile® FLEX2 enables fully integrated automatic sample transfer, analysis, and automated feedback control in each single-use ambr® 15 bioreactor. The combined system provides a unique tool to simultaneously run, sample, and analyze a massive number of cell culture conditions during cell line and media development by Design of Experiments (DoE). SSB and Nova have collaborated to seamlessly integrate the software interface that controls the ambr® 15 workstation for automated parallel processing of 24 or 48 single-use bioreactors (10–15 mL working volume) with the cell culture analysis capabilities of the innovative BioProfile FLEX2. This newly integrated system, which is a first from SSB and Nova’s successful collaboration, enables rapid at-line sample collection and analysis of massive quantities of key cell culture data.

Sartorius Stedim Biotech’s ambr® 15 bioreactor system now can be combined with Nova’s BioProfile® FLEX2 automated cell culture analyzer.Goettingen, Germany - Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry, has announced the ambr® 15 automated micro bioreactor system combined with a Nova Biomedical (Nova) BioProfile® FLEX2 automated cell culture analyzer.